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Case Report
A Case of Familial Hypercholesterolemia with Diabetes Mellitus
Yong Kyu Sohn, Kee Young Chang, Kee Hyoung Lee, Young Chang Tockgo
Clin Exp Pediatr. 1997;40(6):862-866.   Published online June 15, 1997
Familial Hypercholesterolemia is the most common hyperlipoproteinemia during the childhood, which occurs from the mutation of genes that regulates low-density lipoproteins(LDL), and is classified into two types, the homozygote presented abnormal genes from both parents and the heterozygote presented an abnormal gene from each parent. Type IIa familial hypercholesterolemia is characterized by, especially, increased level of LDL which is common type and normal level...
A Case of Mauriac's syndrome
Se Young Kim, Choong Ho Shin, Il Soo Ha, Hae Il Cheong, Sei Won Yang, Yong Choi, Hyung Ro Moon
Clin Exp Pediatr. 1996;39(7):1020-1024.   Published online July 15, 1996
Mauriac's syndrome was described in the 1920s, as a triad of poorly controlled insulin dependent diabetes mellitus, profound growth retardation, and hepatomgaly. Following the wide availability of insulin and intensification of diabetic control, this entity has become quite rare. A 9-year-old female child was transferred to pediatric OPD of SNUCH because of hyperglycemia, short stature, and visual disturbance. Five years prior to admission, she...
Original Article
Sex Hormone Binding Globulin Levels in Children with Insulin Dependent Diabetes Mellitus
Duk Hi Kim, Mi Jung Park, Ho Sung Kim
Clin Exp Pediatr. 1995;38(7):963-969.   Published online July 15, 1995
Purpose : Sex hormone binding globulin(SHBG) is produced in liver and binds to testostero-ne and estradiol. Plasma SHBG levels are increased by estrogen and thyrotoxicosis and decreased by testostrone, insulin, growth hormone, prolactin, obesity and noninsulin dependent diabetes mellitus. SHBG levels in patients with NIDDM is known to be higher than normal, but SHBG levels in children with IDDM is controversial....
Clinical Study on Insulin Dependent Diabetes mellitus
Seog Beom Cho, Kwang Rae Lee, Chang Beom Shin, Oh Kyung Lee, Chong Duk Kim, Oh Kyung Lee
Clin Exp Pediatr. 1995;38(6):827-834.   Published online June 15, 1995
Purpose : Insulin dependet diabetes mellitus(IDDM) is a rare disease in children, but it will progress rapidly and falls into a diabetic ketoacidosis or coma. Unfortunately, the characteristics and prevalence rate of children with IDDM are not well known in Korea. With a view to recognizing its importance, we studied clinical course of IDDM patients in Chonbuk province, Korea. Methods : From...
Case Report
A Case of Diabetes Mellitus due to Hemochromatosis in Patient with CPRCA
Eun Hee Kim, Yong Hwa, Ho Sik, Sung Wom Kim
Clin Exp Pediatr. 1995;38(2):280-284.   Published online February 15, 1995
Iron overload from repeated blood transfusions in patients with hematologic problems is a problem of clinical significance, because eventually it can lead to secondary hemochromatosis with diabetes. So it is important to diagnose iron overload early and to restrict blood transfusions in these patients. Recently, we experienced one case of secondary hemochromatosis with diabetes in patient wi th congenital pure red...
Original Article
Body Composition of Children and Adolescents with Insulin-dependetn Diabetes Mellitus
Hye Young Kang, Mi Jung Park, Duk Hi Kim, You Kyung Park, Jong Ho Lee, Ho Seong Kim
Clin Exp Pediatr. 1994;37(12):1709-1716.   Published online December 15, 1994
Bodycomposition measurement is useful in the diagnosis of pathoogy, assessment of disease process and response to treatment in many endoclonologic and metabolic diseases. The Techniques used currently are mostly indirect, often expensive, difficult and time-consuming. A new method for estimation of body composition, infrared interactance, is rapid, safe, noninvasive, and may be useful in research ad clinical studies. Body composition was...
The Growth Hormone-Binding Proteins in Human Serum: Partial characterization and Regulation
Ji Young Suh, Bu Hun Lee, Jeh Hoon Shin, Hang Lee, Seong Ryul Jang
Clin Exp Pediatr. 1994;37(10):1427-1436.   Published online October 15, 1994
We assessed abotu growth homone binding proteins(GHP|BP) activity which was measured eluted biotin GH fraction with alkaline phosphatase-streptavidine in children with insulin dependent diabetes mellitus(IDDM), short stature due to growth hormone deficiency(GHD), chronic renal failure, short stature due to nutritional deficiency. Hypothyroidism, and noraml control groups using high pressure liquid chromatography protein pak 300 sw column. The following results are observed: 1)...
Case Report
A Case of Miescher Syndrome with Insulin-Resistant Diabetes Mellitus
Byung Min Choi, Jong Kwang Lee, Kee Hwan Yoo, Joo Won Lee, Soon Kyum Kim
Clin Exp Pediatr. 1994;37(9):1292-1295.   Published online September 15, 1994
Miescher syndrome comprises congenital acanthosis nigricans, hypertrichosis, failure to thrive and short stature, dysmorphism especially of the jaws and oral cavity. Insulin-resistant diabetes mellitus, and a characteristic general appearance. This report concerns a rare case of 12-year-old girl having insulin resistant diabetic mellitus with Miescher syndrome. The relevant literature was reviewed.
Original Article
Prevalence of Diabetes Mellitus and Glycosuria in School children
Jae Ho Lee, Kwang Wook Ko
Clin Exp Pediatr. 1994;37(7):986-993.   Published online July 15, 1994
An epidemiological survey on the glycosuria was conducted on the senier students of middle and hign school in Seoul, from March 1981 to March 1982. Selected examinee totalled to 254,835 of which 138,116 were male & 116,719 were female. The initial, second and third urine sugar test were done with Combur-test strip? Glucose tolerance test was performed on those who...
Case Report
A Case of Prader-Willi Syndrome with Diabetes Mellitus
Hee Ran Choi, Eun Ha Choi, Seong Hee Jang, Young Min Ahn
Clin Exp Pediatr. 1994;37(4):565-572.   Published online April 15, 1994
Prader-Willi syndrome is characterized by infantile hypotonia, mental retardation, hyperhagia, hypogonadism and obestiy. Approximately 60% of all PLW syndrome show an interstitial deletion of chromosome 15, 37% have apparently normal chromosome, and 3.6% have a variety of other abnormalities involving chromosome 15. Diabetes mellitus has been considered a component of PLW syndrome and the incidence is about 7%. We...
Original Article
A case of transient diabetes mellitus and diabetic ketoacidosis induced by L-asparaginase and prednisolone administration in a patient with relapsed acute lymphocytic leukemia.
Won Kyu Choi, Mee Kyung Namgoong, Har Yong Lee, Hwang Min Kim, Jong Soo Kim
Clin Exp Pediatr. 1991;34(9):1316-1322.   Published online September 30, 1991
L-asparaginase is known as an effective anticancer drug in the induction chemotherapy of acute lymphocytic leukemia. The side effects or toxicities of L-asparaginase and prednisolone are hypersen- sitivity reaction, hepatotoxicity, pancreatitis and transient diabetes mellitus, CNS toxicity, disorder of coagulation system and mild cytotoxicity. We experienced a case of transient diabetes mellitus and diabetic ketoacidosis induced by L- asparaginase, prednisolone, vincristine and MTX administration in...
A case of IDDM associated with hypothyroidism.
Kyung Min Lee, Kuk Sin Jang, Mi Kyung Jang, Chul Zoo Jung
Clin Exp Pediatr. 1991;34(1):144-147.   Published online January 31, 1991
The authors experienced a case of insulin-dependent diabetes mellitus with hypothyroidism. We recommend that all patients with insulin-dependent diabetes mellitus be screened for thyroid mi- crosomal antibody and that those patients found to have thyroid microsomal antibody be followed annually for determination of free T4 and TSH values. We report this case with a review of related literatures.
HLA Typing, Islet Cell Antibody and C-Peptide of Insulin Dependent Diabetes Mellitus in Children.
Hyeong Rae Cho, Sei Joong Ko, Duk Hi Kim, Hyun Chul Lee, Kap Bum Huh
Clin Exp Pediatr. 1990;33(12):1705-1712.   Published online December 31, 1990
35 childhood insulin-dependent (Typel) diabetes mellitus were typed for HLA and examined for presence of islet cell antibody and level of C-peptide. The following results were obtained: 1) HLA types were present as follows; HLA A24 (9) in 58%, DR3 in 38% and DR4 in 62%. This was slightly higher than the Korean population of 38%, 7% and 48% but there was no significant difference. 2) When...
A Case of Dermatomyositis.
Pal Dong Kim, Chi Han Kwon, Eun Sook Suh, Chin Moo Kang
Clin Exp Pediatr. 1990;33(6):870-878.   Published online June 30, 1990
Dermatomyositis is a rarely recognized disorder with poor prognosis. The mortality has been decreased after the initiation of steroid for ifs treatment. Authors experienced a case of der- matomyositis responded well to prednisone therapy and developed hyperglycemia laterly. A 14 year old boy was admitted to pediatric ward with the chief complaints of progressive muscular weakness and facial rash and diagnosed as having dermatomyositis...
The Findings of 2D and M-mode Echocardiography in Young Insulin-Dependent Diabetes Mellitus.
Byoung Rei Cho, Jae Wook Ko, Young Jin Hong, Don Hee Ahn, Keun Chan Sohn
Clin Exp Pediatr. 1990;33(1):88-93.   Published online January 31, 1990
Twenty-one children and young adults with Insulin-dependent diatetes mellitus and 23 control underwent 2D and M-mode echocardiography. Following results were obtained: 1) LVESD, LVEDD, EF, FS, LAD/AOD ratio, Dm of IVS and Dm of PLVWT were not significantly different in diabetics compared to control subjects. 2) In IDDM PEP was slightly increased and LVET was slightly decreased, but there was not statistical significance between the two groups. But...
A Case of Transient Neonatal Diabetes Mellitus.
Hye Hyun Kim, Kyung Ha Ryu, Keun Lee
Clin Exp Pediatr. 1988;31(10):1346-1349.   Published online October 31, 1988
Transient Neonatal D.M. is rare disease which is characterized by letharginess, dehydration and weight loss with severe hyperglycemia. It occurs frequently which small for data infant and recovers spontaneously if appropriate insulin treatment was taken. We had expirienced a case of Transient Neonatal D.M. in 15 days old female infant. The review of the literature was made briefly.
The Effect of Pertussive Vaccine & Cyclosporin on Streptozotocin Induced Diabetic Rats.
Duk Hi Kim
Clin Exp Pediatr. 1988;31(7):914-923.   Published online July 31, 1988
The injection of streptozotocin (STZ) at higher dose (60 mg/kg) to young male rats produce direct beta cell destruction and lead to insulin dependent diabetes (IDD). In contrast, the injection of multiple smaller dose of STZ (40 mg/kg/d for 5 days) produce IDD, which resembles type 1 diabetes in man. The protective effect of pertussis vaccine (PV) & cyclosporin (CA) against the develoment...
A Study on Serum Growth Hormone in DM of Childhood.
Duk Hi Kim
Clin Exp Pediatr. 1987;30(2):175-180.   Published online February 28, 1987
The human growth hormone (hGH) levels were evaluated in 13 diabetes mellitus, 11 patients were insulin dependent diabetes (ages 2 yr 10 mo to 13 yr 14 mo), 2 patients were noninsulin dependent diabetes (age 12 yr & 12 yr 5 mo). No difference in hGH level was observed in relation to duration of diabetes. The hGH responses to glucagon 1 mg injection in...
The Effects of Cyclosporin in Treatment of Insulin Dependent Diabetes Mellitus.
Duk Hi Kim
Clin Exp Pediatr. 1985;28(6):564-569.   Published online June 30, 1985
A 2 year 10 month old girl with 6 weeks duration and 13 year 4 month old boy with 8 weeks duration were given cyclosporin for 68 days. Therapy was initiated orally at the dosage of 10 mg per kg of body per day. Blood glucose, C-peptide, cyclosporin, creatinin, BUN and transaminase were checked regularly. Cyclosporin treatment allowed two patients to...
A Clinical Study on Insulin Dependent Diabetes Mellitus.
H S Kim, Y K Suh, T W Paik, Y D Kwon, C M Kang
Clin Exp Pediatr. 1984;27(9):903-911.   Published online September 30, 1984
The authors studied twelve cases of insulin dependent diabetes mellitus who were admitted to Pediatric Department of Keimyung University, Dong San Hospital from February 1975 to January 1983. Disease was developed after puberty in eight cases and effected both sexes equally and had tendency, prevalent in winter season. There was no significant family history except one case who had diabetic...
Clinical Observation of Juvenile Diabetes Millitus.
Hae Il Cheong, Dong Gyoon Kim, Yong Choi, Kwang Wook Ko
Clin Exp Pediatr. 1983;26(6):553-563.   Published online June 30, 1983
Clinical data of 33 children with juvenile diabetes mellitus who were admitted to the Seoul National University Hospital from Jan. 1967 to Feb. 1983 were analyzed retrospectively. Male to female ratio was 10:23, the mean age at onset was 6 10/12 years, and there was considerable seasonal variation with peaks in late winter and spring. Polyuria and polydipsia were noted in all cases as...
Case Report
Three Cases of Insulin Dependent Diabetes Mellitus in Children.
Tae Hoon Lee, Sang Chul Park, Chang Hwi Kim, Sang Man Shin, Sang Jhoo Lee
Clin Exp Pediatr. 1983;26(3):285-289.   Published online March 31, 1983
We experienced three cases of Insulin Dependent Diabetes Mellitus, which revealed fullfilling- all characteristics of clinical 技 laboratory finding during recent 3 years. Two diabetic children among three patients had developed diabetic ketoacidosis. The one of the two cases, 14 aged girl complained of dyspnea & severe emaciation. The another case, 11 year and 2 month-old boy who had cataract complained of severe epigastric pain,...
Original Article
Clinical Study of Juvenile Diabetes Mellitus.
Keun chull Choi, Seok ku Kim, Chul Lee, Myung ho Lee
Clin Exp Pediatr. 1982;25(5):489-497.   Published online May 31, 1982
We have observed 9 cases of juvenile diabetes mellitus who were admitted to Pediatrics Department of Presbyterian Medical Center in Jeon-ju, during period of 7 years and 2 months from Jan, 1974 to Mar, 1981. The following results were obtained. 1) Incidence of juvenile diabetes mellitus was 0.088% of all patients who were admitted to Pediatric Department ward during period...
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